Yesterday, while being super-productive in my main project, I stumbled upon (pun intented) thingler and realie, both of which made me say "holy mackerel, this node.js hype looks extra rad!" So a fellow dev and I decided to start a little project to learn this awesome stuff. Maybe sometime in a future in a possible universe I'll post more about that.
Yet we are used to web frameworks, and we felt that we needed at least a templating system. We're leaning toward express because it allows templates in haml with the hamljs module and, while we were at it, decided to take less, the css with steroids, for a spin with the less.js module. Express feels nice, though the documentation is kinda weird (being that is sometimes inconsistent and totally incomplete).
You should check node.js out, feels like the future!